CD73 and AMPD3 deficiency enhance metabolic performance via erythrocyte ATP that decreases hemoglobin oxygen affinity

Erythrocytes are the key target in 5′-AMP induced hypometabolism. To understand how regulation of endogenous erythrocyte AMP levels modulates systemic metabolism, we generated mice deficient in both CD73 and AMPD3, the key catabolic enzymes for extracellular and intra-erythrocyte AMP, respectively....

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Detalles Bibliográficos
Autores principales: O’Brien III, William G., Berka, Vladimir, Tsai, Ah-Lim, Zhao, Zhaoyang, Lee, Cheng Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650700/
https://www.ncbi.nlm.nih.gov/pubmed/26249166
http://dx.doi.org/10.1038/srep13147

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