Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain

Survival and proliferation of cancer cells are often associated with hyperactivity of the serine/threonine kinase, Akt. Herein, we show that prosurvival activity of Akt can be converted into prodeath activity by embedding an Akt recognition sequence in the apoptogenic BH3 domain of human BIM. The re...

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Detalles Bibliográficos
Autores principales: Kim, J-S, Ku, B, Woo, T-G, Oh, A-Y, Jung, Y-S, Soh, Y-M, Yeom, J-H, Lee, K, Park, B-J, Oh, B-H, Ha, N-C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650712/
https://www.ncbi.nlm.nih.gov/pubmed/26136077
http://dx.doi.org/10.1038/cddis.2015.118

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