Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents

Microenvironment-mediated upregulation of the B-cell receptor (BCR) and nuclear factor-κB (NF-κB) signaling in CLL cells resident in the lymph node and bone marrow promotes apoptosis evasion and clonal expansion. We recently reported that MLN4924 (pevonedistat), an investigational agent that inhibit...

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Detalles Bibliográficos
Autores principales: Paiva, C, Godbersen, J C, Berger, A, Brown, J R, Danilov, A V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650717/
https://www.ncbi.nlm.nih.gov/pubmed/26158513
http://dx.doi.org/10.1038/cddis.2015.161

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