Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF)

p53 is the most frequently mutated tumor-suppressor gene in human cancers. Unlike other tumor-suppressor genes, p53 mutations mainly occur as missense mutations within the DNA-binding domain, leading to the expression of full-length mutant p53 protein. Mutant p53 proteins not only lose their tumor-s...

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Detalles Bibliográficos
Autores principales: Tan, B S, Tiong, K H, Choo, H L, Fei-Lei Chung, F, Hii, L-W, Tan, S H, Yap, I KS, Pani, S, Khor, N TW, Wong, S F, Rosli, R, Cheong, S-K, Leong, C-O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650736/
https://www.ncbi.nlm.nih.gov/pubmed/26181206
http://dx.doi.org/10.1038/cddis.2015.191

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