Cargando…
Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis
According to previous studies, the clinical course of sepsis could be affected by preexisting medical conditions, which are very common among patients with sepsis. This observational study aimed at investigating whether common chronic medical conditions affect the 90-day mortality risk in adult Cauc...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650757/ https://www.ncbi.nlm.nih.gov/pubmed/25995131 http://dx.doi.org/10.1038/srep10539 |
_version_ | 1782401553133469696 |
---|---|
author | Mansur, Ashham Mulwande, Evelyn Steinau, Maximilian Bergmann, Ingo Frederik Popov, Aron Ghadimi, Michael Beissbarth, Tim Bauer, Martin Hinz, José |
author_facet | Mansur, Ashham Mulwande, Evelyn Steinau, Maximilian Bergmann, Ingo Frederik Popov, Aron Ghadimi, Michael Beissbarth, Tim Bauer, Martin Hinz, José |
author_sort | Mansur, Ashham |
collection | PubMed |
description | According to previous studies, the clinical course of sepsis could be affected by preexisting medical conditions, which are very common among patients with sepsis. This observational study aimed at investigating whether common chronic medical conditions affect the 90-day mortality risk in adult Caucasian patients with sepsis. A total of 482 patients with sepsis were enrolled in this study. The ninety-day mortality was the primary outcome; organ failure was the secondary outcome. Sepsis-related organ failure assessment (SOFA) scores and the requirements for organ support were evaluated to assess organ failure. A multivariate Cox regression model for the association between the 90-day mortality risk and chronic preexisting medical conditions adjusted for all relevant confounders and mortality predictors revealed the highest hazard ratio for patients with chronic kidney disease (CKD) (hazard ratio, 2.25; 95% CI, 1.46-3.46; p = 0.0002). Patients with CKD had higher SOFA scores than patients without CKD (8.9 ± 4.0 and 6.5 ± 3.4, respectively; p < 0.0001). Additionally, an analysis of organ-specific SOFA scores revealed higher scores in three organ systems (kidney, cardiovascular and coagulation). Patients with CKD have the highest 90-day mortality risk compared with patients without CKD or with other chronic medical conditions. |
format | Online Article Text |
id | pubmed-4650757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46507572015-11-24 Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis Mansur, Ashham Mulwande, Evelyn Steinau, Maximilian Bergmann, Ingo Frederik Popov, Aron Ghadimi, Michael Beissbarth, Tim Bauer, Martin Hinz, José Sci Rep Article According to previous studies, the clinical course of sepsis could be affected by preexisting medical conditions, which are very common among patients with sepsis. This observational study aimed at investigating whether common chronic medical conditions affect the 90-day mortality risk in adult Caucasian patients with sepsis. A total of 482 patients with sepsis were enrolled in this study. The ninety-day mortality was the primary outcome; organ failure was the secondary outcome. Sepsis-related organ failure assessment (SOFA) scores and the requirements for organ support were evaluated to assess organ failure. A multivariate Cox regression model for the association between the 90-day mortality risk and chronic preexisting medical conditions adjusted for all relevant confounders and mortality predictors revealed the highest hazard ratio for patients with chronic kidney disease (CKD) (hazard ratio, 2.25; 95% CI, 1.46-3.46; p = 0.0002). Patients with CKD had higher SOFA scores than patients without CKD (8.9 ± 4.0 and 6.5 ± 3.4, respectively; p < 0.0001). Additionally, an analysis of organ-specific SOFA scores revealed higher scores in three organ systems (kidney, cardiovascular and coagulation). Patients with CKD have the highest 90-day mortality risk compared with patients without CKD or with other chronic medical conditions. Nature Publishing Group 2015-05-21 /pmc/articles/PMC4650757/ /pubmed/25995131 http://dx.doi.org/10.1038/srep10539 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Mansur, Ashham Mulwande, Evelyn Steinau, Maximilian Bergmann, Ingo Frederik Popov, Aron Ghadimi, Michael Beissbarth, Tim Bauer, Martin Hinz, José Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis |
title | Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis |
title_full | Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis |
title_fullStr | Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis |
title_full_unstemmed | Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis |
title_short | Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis |
title_sort | chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650757/ https://www.ncbi.nlm.nih.gov/pubmed/25995131 http://dx.doi.org/10.1038/srep10539 |
work_keys_str_mv | AT mansurashham chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT mulwandeevelyn chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT steinaumaximilian chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT bergmanningo chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT frederikpopovaron chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT ghadimimichael chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT beissbarthtim chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT bauermartin chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis AT hinzjose chronickidneydiseaseisassociatedwithahigher90daymortalitythanotherchronicmedicalconditionsinpatientswithsepsis |