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Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases
The His-x-Asp (HxD) motif is one of the most conserved structural components of the catalytic core of protein kinases; however, the functional role of the conserved histidine is unclear. Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both th...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650784/ https://www.ncbi.nlm.nih.gov/pubmed/25960268 http://dx.doi.org/10.1038/srep10115 |