Cargando…

Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is caused by a trinucleotide CAG repeat in the huntingtin gene (HTT) that results in expression of a polyglutamine-expanded mutant huntingtin protein (mHTT). N-terminal fragments of mHTT accumulate in brain neurons and glia as soluble monomeric and oligomeric species as wel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fox, Jonathan, Lu, Zhen, Barrows, Lorraine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650837/ https://www.ncbi.nlm.nih.gov/pubmed/26664998 http://dx.doi.org/10.1371/currents.hd.b966ec2eca8e2d89d2bb4d020be4351e

Ejemplares similares

Correction: Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington’s Disease
por: PLOS Currents, -
Publicado: (2016)

Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5
por: Guerra, Concetta, et al.
Publicado: (2020)

Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides
por: Pisoni, Giorgia Brambilla, et al.
Publicado: (2015)

Control of Periplasmic Interdomain Thiol:Disulfide Exchange in the Transmembrane Oxidoreductase DsbD
por: Mavridou, Despoina A. I., et al.
Publicado: (2009)

Applications of thiol-disulfide oxidoreductases for optimized in vivo production of functionally active proteins in Bacillus
por: Kouwen, Thijs R. H. M., et al.
Publicado: (2009)

Chemical synthesis of human selenoprotein F and elucidation of its thiol-disulfide oxidoreductase activity
por: Liao, Peisi, et al.
Publicado: (2022)

Functional and Bioinformatics Analysis of Two Campylobacter jejuni Homologs of the Thiol-Disulfide Oxidoreductase, DsbA
por: Grabowska, Anna D., et al.
Publicado: (2014)

Preliminary crystallographic data of the three homologues of the thiol–disulfide oxidoreductase DsbA in Neisseria meningitidis. Corrigendum
por: Lafaye, Céline, et al.
Publicado: (2008)

Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme
por: Oka, Ojore B.V., et al.
Publicado: (2015)

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca(2+) flux
por: Raturi, Arun, et al.
Publicado: (2016)

A placebo-controlled efficacy study of the intravesical immunomodulators TMX-101 and TMX-202 in an orthotopic bladder cancer rat model
por: Falke, Johannes, et al.
Publicado: (2018)

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase
por: Soma, Shivatheja, et al.
Publicado: (2019)

Absence of Thiol-Disulfide Oxidoreductase DsbA Impairs cbb(3)-Type Cytochrome c Oxidase Biogenesis in Rhodobacter capsulatus
por: Onder, Ozlem, et al.
Publicado: (2017)

C8J_1298, a bifunctional thiol oxidoreductase of Campylobacter jejuni, affects Dsb (disulfide bond) network functioning
por: Banaś, Anna Marta, et al.
Publicado: (2020)

Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Applications to seco-Duocarmycins Targeting the Thioredoxin System
por: Felber, Jan G., et al.
Publicado: (2023)

Crystal Structure and Biophysical Properties of Bacillus subtilis BdbD: AN OXIDIZING THIOL:DISULFIDE OXIDOREDUCTASE CONTAINING A NOVEL METAL SITE
por: Crow, Allister, et al.
Publicado: (2009)

Characterization of Striatal Neuronal Loss and Atrophy in the R6/2 Mouse Model of Huntington’s Disease
por: Dodds, Lindsay, et al.
Publicado: (2014)

Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis
por: Ozyurt, Songul, et al.
Publicado: (2022)

Thiol-Disulfide Homeostasis in Skin Diseases
por: Georgescu, Simona Roxana, et al.
Publicado: (2022)

Thiol Quantification Using Colorimetric Thiol–Disulfide Exchange in Nonaqueous Solvents
por: Schmidt, Ryan, et al.
Publicado: (2023)

Mutation of the Streptococcus gordonii Thiol-Disulfide Oxidoreductase SdbA Leads to Enhanced Biofilm Formation Mediated by the CiaRH Two-Component Signaling System
por: Davey, Lauren, et al.
Publicado: (2016)

Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia
por: Şimşek, Özgür, et al.
Publicado: (2018)

Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression
por: Erzin, Gamze, et al.
Publicado: (2020)

Bacterial thiol oxidoreductases — from basic research to new antibacterial strategies
por: Bocian-Ostrzycka, Katarzyna M., et al.
Publicado: (2017)

An investigation of thiol/disulfide homeostasis in patients with Behçet’s disease
por: Sandikci, Sevinc Can, et al.
Publicado: (2019)

Proptosis is associated with thiol-disulfide in patients with Graves’ ophthalmopathy
por: Acibucu, Fettah, et al.
Publicado: (2022)

A Male with Unilateral Microphthalmia Reveals a Role for TMX3 in Eye Development
por: Chao, Ryan, et al.
Publicado: (2010)

Introducing Thioredoxin-Related Transmembrane Proteins: Emerging Roles of Human TMX and Clinical Implications
por: Matsuo, Yoshiyuki
Publicado: (2022)

Glutaredoxins employ parallel monothiol–dithiol mechanisms to catalyze thiol–disulfide exchanges with protein disulfides
por: Ukuwela, Ashwinie A., et al.
Publicado: (2017)

Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism
por: Or, Koca Arzu, et al.
Publicado: (2020)

Is dynamic thiol/disulfide homeostasis associated with the prognosis of myelodysplastic syndrome?
por: Ali, Ucar Mehmet, et al.
Publicado: (2020)

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects
por: EREL, Özcan, et al.
Publicado: (2020)

Thiol/disulfide homeostasis impaired in patients with primary Sjögren's syndrome
por: Yilmaz, Cakmak Nuray, et al.
Publicado: (2021)

Oxidative Stress and Thiol/Disulfide Homeostasis in Human Papillomavirus Infections
por: Sener, Sertac, et al.
Publicado: (2022)

Thiol disulfide homeostasis in ionizing radiation and chemotherapeutic drug exposure
por: Eroglu, Nilgun, et al.
Publicado: (2023)

Impact of selected amino acids of HP0377 (Helicobacter pylori thiol oxidoreductase) on its functioning as a CcmG (cytochrome c maturation) protein and Dsb (disulfide bond) isomerase
por: Grzeszczuk, Magdalena Joanna, et al.
Publicado: (2018)

Fast-Forming Dissolvable Redox-Responsive Hydrogels: Exploiting the Orthogonality of Thiol–Maleimide and Thiol–Disulfide Exchange Chemistry
por: Altinbasak, Ismail, et al.
Publicado: (2022)

Neonatal Iron Supplementation Induces Striatal Atrophy in Female YAC128 Huntington’s Disease Mice
por: Berggren, Kiersten L., et al.
Publicado: (2016)

A Structure-Based Approach for Detection of Thiol Oxidoreductases and Their Catalytic Redox-Active Cysteine Residues
por: Marino, Stefano M., et al.
Publicado: (2009)

Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress
por: Kranz, Philip, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7lk5pd24skq3ecmed3uajiin2b