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Integrating transcriptional and protein interaction networks to prioritize condition-specific master regulators

BACKGROUND: Genome-wide libraries of yeast deletion strains have been used to screen for genes that drive phenotypes such as stress response. A surprising observation emerging from these studies is that the genes with the largest changes in mRNA expression during a state transition are not those tha...

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Detalles Bibliográficos
Autores principales: Padi, Megha, Quackenbush, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650867/
https://www.ncbi.nlm.nih.gov/pubmed/26576632
http://dx.doi.org/10.1186/s12918-015-0228-1