Cargando…

Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents

BACKGROUND: Depression in adolescence is debilitating with high recurrence in adulthood, yet its pathophysiological mechanism remains enigmatic. To examine the interaction between emotion, cognition and treatment, functional brain responses to sad and happy distractors in an affective go/no-go task...

Descripción completa

Detalles Bibliográficos
Autores principales: Chuang, Jie-Yu, J Whitaker, Kirstie, Murray, Graham K, Elliott, Rebecca, Hagan, Cindy C, Graham, Julia ME, Ooi, Cinly, Tait, Roger, Holt, Rosemary J, van Nieuwenhuizen, Adrienne O, Reynolds, Shirley, Wilkinson, Paul O, Bullmore, Edward T, Lennox, Belinda R, Sahakian, Barbara J, Goodyer, Ian, Suckling, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650987/
https://www.ncbi.nlm.nih.gov/pubmed/26406969
http://dx.doi.org/10.1016/j.jad.2015.09.008
_version_ 1782401596098871296
author Chuang, Jie-Yu
J Whitaker, Kirstie
Murray, Graham K
Elliott, Rebecca
Hagan, Cindy C
Graham, Julia ME
Ooi, Cinly
Tait, Roger
Holt, Rosemary J
van Nieuwenhuizen, Adrienne O
Reynolds, Shirley
Wilkinson, Paul O
Bullmore, Edward T
Lennox, Belinda R
Sahakian, Barbara J
Goodyer, Ian
Suckling, John
author_facet Chuang, Jie-Yu
J Whitaker, Kirstie
Murray, Graham K
Elliott, Rebecca
Hagan, Cindy C
Graham, Julia ME
Ooi, Cinly
Tait, Roger
Holt, Rosemary J
van Nieuwenhuizen, Adrienne O
Reynolds, Shirley
Wilkinson, Paul O
Bullmore, Edward T
Lennox, Belinda R
Sahakian, Barbara J
Goodyer, Ian
Suckling, John
author_sort Chuang, Jie-Yu
collection PubMed
description BACKGROUND: Depression in adolescence is debilitating with high recurrence in adulthood, yet its pathophysiological mechanism remains enigmatic. To examine the interaction between emotion, cognition and treatment, functional brain responses to sad and happy distractors in an affective go/no-go task were explored before and after Cognitive Behavioural Therapy (CBT) in depressed female adolescents, and healthy participants. METHODS: Eighty-two Depressed and 24 healthy female adolescents, aged 12–17 years, performed a functional magnetic resonance imaging (fMRI) affective go/no-go task at baseline. Participants were instructed to withhold their responses upon seeing happy or sad words. Among these participants, 13 patients had CBT over approximately 30 weeks. These participants and 20 matched controls then repeated the task. RESULTS: At baseline, increased activation in response to happy relative to neutral distractors was observed in the orbitofrontal cortex in depressed patients which was normalised after CBT. No significant group differences were found behaviourally or in brain activation in response to sad distractors. Improvements in symptoms (mean: 9.31, 95% CI: 5.35–13.27) were related at trend-level to activation changes in orbitofrontal cortex. LIMITATIONS: In the follow-up section, a limited number of post-CBT patients were recruited. CONCLUSIONS: To our knowledge, this is the first fMRI study addressing the effect of CBT in adolescent depression. Although a bias toward negative information is widely accepted as a hallmark of depression, aberrant brain hyperactivity to positive distractors was found and normalised after CBT. Research, assessment and treatment focused on positive stimuli could be a future consideration. Moreover, a pathophysiological mechanism distinct from adult depression may be suggested and awaits further exploration.
format Online
Article
Text
id pubmed-4650987
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier/North-Holland Biomedical Press
record_format MEDLINE/PubMed
spelling pubmed-46509872016-01-01 Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents Chuang, Jie-Yu J Whitaker, Kirstie Murray, Graham K Elliott, Rebecca Hagan, Cindy C Graham, Julia ME Ooi, Cinly Tait, Roger Holt, Rosemary J van Nieuwenhuizen, Adrienne O Reynolds, Shirley Wilkinson, Paul O Bullmore, Edward T Lennox, Belinda R Sahakian, Barbara J Goodyer, Ian Suckling, John J Affect Disord Research Report BACKGROUND: Depression in adolescence is debilitating with high recurrence in adulthood, yet its pathophysiological mechanism remains enigmatic. To examine the interaction between emotion, cognition and treatment, functional brain responses to sad and happy distractors in an affective go/no-go task were explored before and after Cognitive Behavioural Therapy (CBT) in depressed female adolescents, and healthy participants. METHODS: Eighty-two Depressed and 24 healthy female adolescents, aged 12–17 years, performed a functional magnetic resonance imaging (fMRI) affective go/no-go task at baseline. Participants were instructed to withhold their responses upon seeing happy or sad words. Among these participants, 13 patients had CBT over approximately 30 weeks. These participants and 20 matched controls then repeated the task. RESULTS: At baseline, increased activation in response to happy relative to neutral distractors was observed in the orbitofrontal cortex in depressed patients which was normalised after CBT. No significant group differences were found behaviourally or in brain activation in response to sad distractors. Improvements in symptoms (mean: 9.31, 95% CI: 5.35–13.27) were related at trend-level to activation changes in orbitofrontal cortex. LIMITATIONS: In the follow-up section, a limited number of post-CBT patients were recruited. CONCLUSIONS: To our knowledge, this is the first fMRI study addressing the effect of CBT in adolescent depression. Although a bias toward negative information is widely accepted as a hallmark of depression, aberrant brain hyperactivity to positive distractors was found and normalised after CBT. Research, assessment and treatment focused on positive stimuli could be a future consideration. Moreover, a pathophysiological mechanism distinct from adult depression may be suggested and awaits further exploration. Elsevier/North-Holland Biomedical Press 2016-01-01 /pmc/articles/PMC4650987/ /pubmed/26406969 http://dx.doi.org/10.1016/j.jad.2015.09.008 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Report
Chuang, Jie-Yu
J Whitaker, Kirstie
Murray, Graham K
Elliott, Rebecca
Hagan, Cindy C
Graham, Julia ME
Ooi, Cinly
Tait, Roger
Holt, Rosemary J
van Nieuwenhuizen, Adrienne O
Reynolds, Shirley
Wilkinson, Paul O
Bullmore, Edward T
Lennox, Belinda R
Sahakian, Barbara J
Goodyer, Ian
Suckling, John
Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents
title Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents
title_full Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents
title_fullStr Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents
title_full_unstemmed Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents
title_short Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents
title_sort aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650987/
https://www.ncbi.nlm.nih.gov/pubmed/26406969
http://dx.doi.org/10.1016/j.jad.2015.09.008
work_keys_str_mv AT chuangjieyu aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT jwhitakerkirstie aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT murraygrahamk aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT elliottrebecca aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT hagancindyc aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT grahamjuliame aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT ooicinly aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT taitroger aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT holtrosemaryj aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT vannieuwenhuizenadrienneo aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT reynoldsshirley aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT wilkinsonpaulo aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT bullmoreedwardt aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT lennoxbelindar aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT sahakianbarbaraj aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT goodyerian aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents
AT sucklingjohn aberrantbrainresponsestoemotionallyvalentwordsisnormalisedaftercognitivebehaviouraltherapyinfemaledepressedadolescents