Cargando…
The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer
BACKGROUND: Tumour budding has previously been reported to predict survival in several solid organ tumours, including breast; however, whether this is independent of other aspects of the tumour microenvironment is unknown. In the present study, the relationship between tumour budding, the tumour mic...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651125/ https://www.ncbi.nlm.nih.gov/pubmed/26263482 http://dx.doi.org/10.1038/bjc.2015.287 |
_version_ | 1782401603903422464 |
---|---|
author | Gujam, F J A McMillan, D C Mohammed, Z M A Edwards, J Going, J J |
author_facet | Gujam, F J A McMillan, D C Mohammed, Z M A Edwards, J Going, J J |
author_sort | Gujam, F J A |
collection | PubMed |
description | BACKGROUND: Tumour budding has previously been reported to predict survival in several solid organ tumours, including breast; however, whether this is independent of other aspects of the tumour microenvironment is unknown. In the present study, the relationship between tumour budding, the tumour microenvironment and survival was examined in patients with invasive ductal breast cancer. METHODS: Patients presenting between 1995 and 1998 were studied (n=474). Using routine pathological sections, tumour budding was measured at the invasive margin and its association with clinicopathological characteristics and cancer-specific survival (CSS) was examined. RESULTS: Tumour budding was associated with several adverse pathological characteristics, including lymph node involvement, lymph vessel invasion (LVI), increased tumour stroma percentage (TSP) and weaker local inflammatory infiltrative. Tumour budding was associated with reduced CSS (hazard ratio (HR) 2.08, 95% confidence interval (CI) 1.14–3.09, P=0.004), independent of nodal status, molecular subtypes, tumour necrosis, CD8+, CD138+, LVI, blood vessel invasion and TSP. Further, tumour budding was independently associated with reduced CSS in node-negative patients (HR 2.63, 95% CI 1.16–5.92, P=0.020) and those who have low TSP (HR 1.98, 95% CI 1.09–3.57, P=0.024) and high-grade local inflammatory infiltrative (HR 2.27, 95% CI 1.35–5.36, P=0.014). CONCLUSIONS: Tumour budding was a significant predictor of survival in patients with invasive ductal breast cancer, independent of adverse pathological characteristics and components of tumour microenvironment. The present study further confirms the clinical utility of both tumour and host-based factors of tumour microenvironment. |
format | Online Article Text |
id | pubmed-4651125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46511252016-09-29 The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer Gujam, F J A McMillan, D C Mohammed, Z M A Edwards, J Going, J J Br J Cancer Molecular Diagnostics BACKGROUND: Tumour budding has previously been reported to predict survival in several solid organ tumours, including breast; however, whether this is independent of other aspects of the tumour microenvironment is unknown. In the present study, the relationship between tumour budding, the tumour microenvironment and survival was examined in patients with invasive ductal breast cancer. METHODS: Patients presenting between 1995 and 1998 were studied (n=474). Using routine pathological sections, tumour budding was measured at the invasive margin and its association with clinicopathological characteristics and cancer-specific survival (CSS) was examined. RESULTS: Tumour budding was associated with several adverse pathological characteristics, including lymph node involvement, lymph vessel invasion (LVI), increased tumour stroma percentage (TSP) and weaker local inflammatory infiltrative. Tumour budding was associated with reduced CSS (hazard ratio (HR) 2.08, 95% confidence interval (CI) 1.14–3.09, P=0.004), independent of nodal status, molecular subtypes, tumour necrosis, CD8+, CD138+, LVI, blood vessel invasion and TSP. Further, tumour budding was independently associated with reduced CSS in node-negative patients (HR 2.63, 95% CI 1.16–5.92, P=0.020) and those who have low TSP (HR 1.98, 95% CI 1.09–3.57, P=0.024) and high-grade local inflammatory infiltrative (HR 2.27, 95% CI 1.35–5.36, P=0.014). CONCLUSIONS: Tumour budding was a significant predictor of survival in patients with invasive ductal breast cancer, independent of adverse pathological characteristics and components of tumour microenvironment. The present study further confirms the clinical utility of both tumour and host-based factors of tumour microenvironment. Nature Publishing Group 2015-09-29 2015-08-11 /pmc/articles/PMC4651125/ /pubmed/26263482 http://dx.doi.org/10.1038/bjc.2015.287 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Molecular Diagnostics Gujam, F J A McMillan, D C Mohammed, Z M A Edwards, J Going, J J The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer |
title | The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer |
title_full | The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer |
title_fullStr | The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer |
title_full_unstemmed | The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer |
title_short | The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer |
title_sort | relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer |
topic | Molecular Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651125/ https://www.ncbi.nlm.nih.gov/pubmed/26263482 http://dx.doi.org/10.1038/bjc.2015.287 |
work_keys_str_mv | AT gujamfja therelationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT mcmillandc therelationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT mohammedzma therelationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT edwardsj therelationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT goingjj therelationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT gujamfja relationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT mcmillandc relationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT mohammedzma relationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT edwardsj relationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer AT goingjj relationshipbetweentumourbuddingthetumourmicroenvironmentandsurvivalinpatientswithinvasiveductalbreastcancer |