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Planarians: an In Vivo Model for Regenerative Medicine

The emergence of regenerative medicine has raised the hope of treating an extraordinary range of disease and serious injuries. Understanding the processes of cell proliferation, differentiation and pattern formation in regenerative organisms could help find ways to enhance the poor regenerative abil...

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Autores principales: Karami, Ali, Tebyanian, Hamid, Goodarzi, Vahabodin, Shiri, Sajad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651277/
https://www.ncbi.nlm.nih.gov/pubmed/26634061
http://dx.doi.org/10.15283/ijsc.2015.8.2.128
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author Karami, Ali
Tebyanian, Hamid
Goodarzi, Vahabodin
Shiri, Sajad
author_facet Karami, Ali
Tebyanian, Hamid
Goodarzi, Vahabodin
Shiri, Sajad
author_sort Karami, Ali
collection PubMed
description The emergence of regenerative medicine has raised the hope of treating an extraordinary range of disease and serious injuries. Understanding the processes of cell proliferation, differentiation and pattern formation in regenerative organisms could help find ways to enhance the poor regenerative abilities shown by many other animals, including humans. Recently, planarians have emerged as an attractive model in which to study regeneration. These animals are considering as in vivo plate, during which we can study the behavior and characristics of stem cells in their own niche. A variety of characteristic such as: simplicity, easy to manipulate experimentally, the existence of more than 100 years of literature, makes these animals an extraordinary model for regenerative medicine researches. Among planarians free-living freshwater hermaphrodite Schmidtea mediterranea has emerged as a suitable model system because it displays robust regenerative properties and, unlike most other planarians, it is a stable diploid with a genome size of about 4.8×10(8) base pairs, nearly half that of other common planarians. Planarian regeneration involves two highly flexible systems: pluripotent neoblasts that can generate any new cell type and muscle cells that provide positional instructions for the regeneration of anybody region. neoblasts represent roughly 25~30 percent of all planarian cells and are scattered broadly through the parenchyma, being absent only from the animal head tips and the pharynx. Two models for neo-blast specification have been proposed; the naive model posits that all neoblasts are stem cells with the same potential and are a largely homogeneous population.
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spelling pubmed-46512772015-12-02 Planarians: an In Vivo Model for Regenerative Medicine Karami, Ali Tebyanian, Hamid Goodarzi, Vahabodin Shiri, Sajad Int J Stem Cells Review Article The emergence of regenerative medicine has raised the hope of treating an extraordinary range of disease and serious injuries. Understanding the processes of cell proliferation, differentiation and pattern formation in regenerative organisms could help find ways to enhance the poor regenerative abilities shown by many other animals, including humans. Recently, planarians have emerged as an attractive model in which to study regeneration. These animals are considering as in vivo plate, during which we can study the behavior and characristics of stem cells in their own niche. A variety of characteristic such as: simplicity, easy to manipulate experimentally, the existence of more than 100 years of literature, makes these animals an extraordinary model for regenerative medicine researches. Among planarians free-living freshwater hermaphrodite Schmidtea mediterranea has emerged as a suitable model system because it displays robust regenerative properties and, unlike most other planarians, it is a stable diploid with a genome size of about 4.8×10(8) base pairs, nearly half that of other common planarians. Planarian regeneration involves two highly flexible systems: pluripotent neoblasts that can generate any new cell type and muscle cells that provide positional instructions for the regeneration of anybody region. neoblasts represent roughly 25~30 percent of all planarian cells and are scattered broadly through the parenchyma, being absent only from the animal head tips and the pharynx. Two models for neo-blast specification have been proposed; the naive model posits that all neoblasts are stem cells with the same potential and are a largely homogeneous population. Korean Society for Stem Cell Research 2015-11 /pmc/articles/PMC4651277/ /pubmed/26634061 http://dx.doi.org/10.15283/ijsc.2015.8.2.128 Text en Copyright ©2015, Korean Society for Stem Cell Research This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Karami, Ali
Tebyanian, Hamid
Goodarzi, Vahabodin
Shiri, Sajad
Planarians: an In Vivo Model for Regenerative Medicine
title Planarians: an In Vivo Model for Regenerative Medicine
title_full Planarians: an In Vivo Model for Regenerative Medicine
title_fullStr Planarians: an In Vivo Model for Regenerative Medicine
title_full_unstemmed Planarians: an In Vivo Model for Regenerative Medicine
title_short Planarians: an In Vivo Model for Regenerative Medicine
title_sort planarians: an in vivo model for regenerative medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651277/
https://www.ncbi.nlm.nih.gov/pubmed/26634061
http://dx.doi.org/10.15283/ijsc.2015.8.2.128
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