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First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent

We previously identified ONC201 (TIC10) as a first-in-class orally active small molecule with robust antitumor activity that is currently in clinical trials in advanced cancers. Here, we further investigate the safety characteristics of ONC201 in preclinical models that reveal an excellent safety pr...

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Detalles Bibliográficos
Autores principales: Allen, Joshua E., Crowder, Roslyn, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651306/
https://www.ncbi.nlm.nih.gov/pubmed/26580220
http://dx.doi.org/10.1371/journal.pone.0143082

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