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Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features

BACKGROUND: Individuals at high risk to develop alcoholism often manifest neurocognitive deficits as well as increased impulsivity. Event-related oscillations (EROs) have been used to effectively measure brain (dys)function during cognitive tasks in individuals with alcoholism and related disorders...

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Autores principales: Kamarajan, Chella, Pandey, Ashwini K., Chorlian, David B., Manz, Niklas, Stimus, Arthur T., Anokhin, Andrey P., Bauer, Lance O., Kuperman, Samuel, Kramer, John, Bucholz, Kathleen K., Schuckit, Marc A., Hesselbrock, Victor M., Porjesz, Bernice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651365/
https://www.ncbi.nlm.nih.gov/pubmed/26580209
http://dx.doi.org/10.1371/journal.pone.0142659
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author Kamarajan, Chella
Pandey, Ashwini K.
Chorlian, David B.
Manz, Niklas
Stimus, Arthur T.
Anokhin, Andrey P.
Bauer, Lance O.
Kuperman, Samuel
Kramer, John
Bucholz, Kathleen K.
Schuckit, Marc A.
Hesselbrock, Victor M.
Porjesz, Bernice
author_facet Kamarajan, Chella
Pandey, Ashwini K.
Chorlian, David B.
Manz, Niklas
Stimus, Arthur T.
Anokhin, Andrey P.
Bauer, Lance O.
Kuperman, Samuel
Kramer, John
Bucholz, Kathleen K.
Schuckit, Marc A.
Hesselbrock, Victor M.
Porjesz, Bernice
author_sort Kamarajan, Chella
collection PubMed
description BACKGROUND: Individuals at high risk to develop alcoholism often manifest neurocognitive deficits as well as increased impulsivity. Event-related oscillations (EROs) have been used to effectively measure brain (dys)function during cognitive tasks in individuals with alcoholism and related disorders and in those at risk to develop these disorders. The current study examines ERO theta power during reward processing as well as impulsivity in adolescent and young adult subjects at high risk for alcoholism. METHODS: EROs were recorded during a monetary gambling task (MGT) in 12–25 years old participants (N = 1821; males = 48%) from high risk alcoholic families (HR, N = 1534) and comparison low risk community families (LR, N = 287) from the Collaborative Study on the Genetics of Alcoholism (COGA). Impulsivity scores and prevalence of externalizing diagnoses were also compared between LR and HR groups. RESULTS: HR offspring showed lower theta power and decreased current source density (CSD) activity than LR offspring during loss and gain conditions. Younger males had higher theta power than younger females in both groups, while the older HR females showed more theta power than older HR males. Younger subjects showed higher theta power than older subjects in each comparison. Differences in topography (i.e., frontalization) between groups were also observed. Further, HR subjects across gender had higher impulsivity scores and increased prevalence of externalizing disorders compared to LR subjects. CONCLUSIONS: As theta power during reward processing is found to be lower not only in alcoholics, but also in HR subjects, it is proposed that reduced reward-related theta power, in addition to impulsivity and externalizing features, may be related in a predisposition to develop alcoholism and related disorders.
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spelling pubmed-46513652015-11-25 Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features Kamarajan, Chella Pandey, Ashwini K. Chorlian, David B. Manz, Niklas Stimus, Arthur T. Anokhin, Andrey P. Bauer, Lance O. Kuperman, Samuel Kramer, John Bucholz, Kathleen K. Schuckit, Marc A. Hesselbrock, Victor M. Porjesz, Bernice PLoS One Research Article BACKGROUND: Individuals at high risk to develop alcoholism often manifest neurocognitive deficits as well as increased impulsivity. Event-related oscillations (EROs) have been used to effectively measure brain (dys)function during cognitive tasks in individuals with alcoholism and related disorders and in those at risk to develop these disorders. The current study examines ERO theta power during reward processing as well as impulsivity in adolescent and young adult subjects at high risk for alcoholism. METHODS: EROs were recorded during a monetary gambling task (MGT) in 12–25 years old participants (N = 1821; males = 48%) from high risk alcoholic families (HR, N = 1534) and comparison low risk community families (LR, N = 287) from the Collaborative Study on the Genetics of Alcoholism (COGA). Impulsivity scores and prevalence of externalizing diagnoses were also compared between LR and HR groups. RESULTS: HR offspring showed lower theta power and decreased current source density (CSD) activity than LR offspring during loss and gain conditions. Younger males had higher theta power than younger females in both groups, while the older HR females showed more theta power than older HR males. Younger subjects showed higher theta power than older subjects in each comparison. Differences in topography (i.e., frontalization) between groups were also observed. Further, HR subjects across gender had higher impulsivity scores and increased prevalence of externalizing disorders compared to LR subjects. CONCLUSIONS: As theta power during reward processing is found to be lower not only in alcoholics, but also in HR subjects, it is proposed that reduced reward-related theta power, in addition to impulsivity and externalizing features, may be related in a predisposition to develop alcoholism and related disorders. Public Library of Science 2015-11-18 /pmc/articles/PMC4651365/ /pubmed/26580209 http://dx.doi.org/10.1371/journal.pone.0142659 Text en © 2015 Kamarajan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kamarajan, Chella
Pandey, Ashwini K.
Chorlian, David B.
Manz, Niklas
Stimus, Arthur T.
Anokhin, Andrey P.
Bauer, Lance O.
Kuperman, Samuel
Kramer, John
Bucholz, Kathleen K.
Schuckit, Marc A.
Hesselbrock, Victor M.
Porjesz, Bernice
Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features
title Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features
title_full Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features
title_fullStr Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features
title_full_unstemmed Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features
title_short Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features
title_sort deficient event-related theta oscillations in individuals at risk for alcoholism: a study of reward processing and impulsivity features
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651365/
https://www.ncbi.nlm.nih.gov/pubmed/26580209
http://dx.doi.org/10.1371/journal.pone.0142659
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