Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice

The destruction of beta cells in type 1 diabetes (T1D) results in loss of insulin production and glucose homeostasis. Treatment of non-obese diabetic (NOD) mice with immune-depleting/modulating agents (e.g., anti-CD3, murine anti-thymocyte-globulin (mATG)) can lead to diabetes reversal. However, for...

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Detalles Bibliográficos
Autores principales: Gagliani, Nicola, Jofra, Tatiana, Posgai, Amanda L., Atkinson, Mark A., Battaglia, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651367/
https://www.ncbi.nlm.nih.gov/pubmed/26580221
http://dx.doi.org/10.1371/journal.pone.0142318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651367/
https://www.ncbi.nlm.nih.gov/pubmed/26580221
http://dx.doi.org/10.1371/journal.pone.0142318

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