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Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice

The destruction of beta cells in type 1 diabetes (T1D) results in loss of insulin production and glucose homeostasis. Treatment of non-obese diabetic (NOD) mice with immune-depleting/modulating agents (e.g., anti-CD3, murine anti-thymocyte-globulin (mATG)) can lead to diabetes reversal. However, for...

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Detalles Bibliográficos
Autores principales:	Gagliani, Nicola, Jofra, Tatiana, Posgai, Amanda L., Atkinson, Mark A., Battaglia, Manuela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651367/ https://www.ncbi.nlm.nih.gov/pubmed/26580221 http://dx.doi.org/10.1371/journal.pone.0142318

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