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Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait

BACKGROUND: Recent studies show that besides freezing of gait (FOG), many people with Parkinson’s disease (PD) also suffer from freezing in the upper limbs (FOUL). Up to now, it is unclear which task constraints provoke and explain upper limb freezing. OBJECTIVE: To investigate whether upper limb fr...

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Autores principales: Heremans, Elke, Nackaerts, Evelien, Vervoort, Griet, Vercruysse, Sarah, Broeder, Sanne, Strouwen, Carolien, Swinnen, Stephan P., Nieuwboer, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651469/
https://www.ncbi.nlm.nih.gov/pubmed/26580556
http://dx.doi.org/10.1371/journal.pone.0142874
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author Heremans, Elke
Nackaerts, Evelien
Vervoort, Griet
Vercruysse, Sarah
Broeder, Sanne
Strouwen, Carolien
Swinnen, Stephan P.
Nieuwboer, Alice
author_facet Heremans, Elke
Nackaerts, Evelien
Vervoort, Griet
Vercruysse, Sarah
Broeder, Sanne
Strouwen, Carolien
Swinnen, Stephan P.
Nieuwboer, Alice
author_sort Heremans, Elke
collection PubMed
description BACKGROUND: Recent studies show that besides freezing of gait (FOG), many people with Parkinson’s disease (PD) also suffer from freezing in the upper limbs (FOUL). Up to now, it is unclear which task constraints provoke and explain upper limb freezing. OBJECTIVE: To investigate whether upper limb freezing and other kinematic abnormalities during writing are provoked by (i) gradual changes in amplitude or by (ii) sustained amplitude generation in patients with and without freezing of gait. METHODS: Thirty-four patients with PD, including 17 with and 17 without FOG, performed a writing task on a touch-sensitive writing tablet requiring writing at constant small and large size as well as writing at gradually increasing and decreasing size. Patients of both groups were matched for disease severity, tested while ‘on’ medication and compared to healthy age-matched controls. RESULTS: Fifty upper limb freezing episodes were detected in 10 patients, including 8 with and 2 without FOG. The majority of the episodes occurred when participants had to write at small or gradually decreasing size. The occurrence of FOUL and the number of FOUL episodes per patient significantly correlated with the occurrence and severity of FOG. Patients with FOUL also showed a significantly smaller amplitude in the writing parts outside the freezing episodes. CONCLUSIONS: Corroborating findings of gait research, the current study supports a core problem in amplitude control underlying FOUL, both in maintaining as well as in flexibly adapting the cycle size.
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spelling pubmed-46514692015-11-25 Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait Heremans, Elke Nackaerts, Evelien Vervoort, Griet Vercruysse, Sarah Broeder, Sanne Strouwen, Carolien Swinnen, Stephan P. Nieuwboer, Alice PLoS One Research Article BACKGROUND: Recent studies show that besides freezing of gait (FOG), many people with Parkinson’s disease (PD) also suffer from freezing in the upper limbs (FOUL). Up to now, it is unclear which task constraints provoke and explain upper limb freezing. OBJECTIVE: To investigate whether upper limb freezing and other kinematic abnormalities during writing are provoked by (i) gradual changes in amplitude or by (ii) sustained amplitude generation in patients with and without freezing of gait. METHODS: Thirty-four patients with PD, including 17 with and 17 without FOG, performed a writing task on a touch-sensitive writing tablet requiring writing at constant small and large size as well as writing at gradually increasing and decreasing size. Patients of both groups were matched for disease severity, tested while ‘on’ medication and compared to healthy age-matched controls. RESULTS: Fifty upper limb freezing episodes were detected in 10 patients, including 8 with and 2 without FOG. The majority of the episodes occurred when participants had to write at small or gradually decreasing size. The occurrence of FOUL and the number of FOUL episodes per patient significantly correlated with the occurrence and severity of FOG. Patients with FOUL also showed a significantly smaller amplitude in the writing parts outside the freezing episodes. CONCLUSIONS: Corroborating findings of gait research, the current study supports a core problem in amplitude control underlying FOUL, both in maintaining as well as in flexibly adapting the cycle size. Public Library of Science 2015-11-18 /pmc/articles/PMC4651469/ /pubmed/26580556 http://dx.doi.org/10.1371/journal.pone.0142874 Text en © 2015 Heremans et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Heremans, Elke
Nackaerts, Evelien
Vervoort, Griet
Vercruysse, Sarah
Broeder, Sanne
Strouwen, Carolien
Swinnen, Stephan P.
Nieuwboer, Alice
Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait
title Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait
title_full Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait
title_fullStr Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait
title_full_unstemmed Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait
title_short Amplitude Manipulation Evokes Upper Limb Freezing during Handwriting in Patients with Parkinson’s Disease with Freezing of Gait
title_sort amplitude manipulation evokes upper limb freezing during handwriting in patients with parkinson’s disease with freezing of gait
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651469/
https://www.ncbi.nlm.nih.gov/pubmed/26580556
http://dx.doi.org/10.1371/journal.pone.0142874
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