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Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI
Registration of subject and control brains to a common anatomical space or template is the basis for quantitatively delineating regions of abnormality in an individual brain. Normally, a brain atlas is chosen as the template. Limitations in the registration process result in persistent differences b...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651497/ https://www.ncbi.nlm.nih.gov/pubmed/26580077 http://dx.doi.org/10.1371/journal.pone.0142288 |
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author | Suri, Asif K. Fleysher, Roman Lipton, Michael L. |
author_facet | Suri, Asif K. Fleysher, Roman Lipton, Michael L. |
author_sort | Suri, Asif K. |
collection | PubMed |
description | Registration of subject and control brains to a common anatomical space or template is the basis for quantitatively delineating regions of abnormality in an individual brain. Normally, a brain atlas is chosen as the template. Limitations in the registration process result in persistent differences between individual subject brains and template, which can be a source of error in an analysis. We propose a new approach to the registration process where the subject of interest is the registration template. Through this change, we eliminate errors due to differences between a brain template and a subject’s brain. We applied this method to the analysis of FA values derived from DTI data of 20 individual mTBI patients as compared to 48 healthy controls. Subject-centered analysis resulted in identification of significantly fewer regions of abnormally low FA compared to two separate atlas-centered analyses, with subject-centered abnormalities essentially representing the common subset of abnormal low FA regions detected by the two atlas-centered methods. Whereas each atlas-centered approach demonstrated abnormalities in nearly every subject (19/20 and 20/20), the subject-centered approach demonstrated abnormalities in fewer than half the subjects (9/20). This reduction of diffusion abnormalities observed using the subject-centered approach is due to elimination of misregistration errors that occur when registering the subject of interest to a template. Evaluation of atlas-centered analyses demonstrated that 9.8% to 13.3% of subject GM and CSF was misregistered onto the WM of the brain atlas, resulting in the observation of additional low FA clusters compared to the subject-centered approach. Without careful evaluation, these misregistrations could be misinterpreted as pathology. An additional benefit of the subject-centered approach is that diffusion abnormalities can now be visualized directly in the subject’s anatomical space, rather than interpolating results from the brain atlas space, and can thereby enhance correlation with other components of an imaging protocol. |
format | Online Article Text |
id | pubmed-4651497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46514972015-11-25 Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI Suri, Asif K. Fleysher, Roman Lipton, Michael L. PLoS One Research Article Registration of subject and control brains to a common anatomical space or template is the basis for quantitatively delineating regions of abnormality in an individual brain. Normally, a brain atlas is chosen as the template. Limitations in the registration process result in persistent differences between individual subject brains and template, which can be a source of error in an analysis. We propose a new approach to the registration process where the subject of interest is the registration template. Through this change, we eliminate errors due to differences between a brain template and a subject’s brain. We applied this method to the analysis of FA values derived from DTI data of 20 individual mTBI patients as compared to 48 healthy controls. Subject-centered analysis resulted in identification of significantly fewer regions of abnormally low FA compared to two separate atlas-centered analyses, with subject-centered abnormalities essentially representing the common subset of abnormal low FA regions detected by the two atlas-centered methods. Whereas each atlas-centered approach demonstrated abnormalities in nearly every subject (19/20 and 20/20), the subject-centered approach demonstrated abnormalities in fewer than half the subjects (9/20). This reduction of diffusion abnormalities observed using the subject-centered approach is due to elimination of misregistration errors that occur when registering the subject of interest to a template. Evaluation of atlas-centered analyses demonstrated that 9.8% to 13.3% of subject GM and CSF was misregistered onto the WM of the brain atlas, resulting in the observation of additional low FA clusters compared to the subject-centered approach. Without careful evaluation, these misregistrations could be misinterpreted as pathology. An additional benefit of the subject-centered approach is that diffusion abnormalities can now be visualized directly in the subject’s anatomical space, rather than interpolating results from the brain atlas space, and can thereby enhance correlation with other components of an imaging protocol. Public Library of Science 2015-11-18 /pmc/articles/PMC4651497/ /pubmed/26580077 http://dx.doi.org/10.1371/journal.pone.0142288 Text en © 2015 Suri et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Suri, Asif K. Fleysher, Roman Lipton, Michael L. Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI |
title | Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI |
title_full | Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI |
title_fullStr | Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI |
title_full_unstemmed | Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI |
title_short | Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI |
title_sort | subject based registration for individualized analysis of diffusion tensor mri |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651497/ https://www.ncbi.nlm.nih.gov/pubmed/26580077 http://dx.doi.org/10.1371/journal.pone.0142288 |
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