Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer

STAT3 overactivation is a common event in many cancers, including head and neck squamous cell carcinoma (HNSCC), where STAT3 represents a promising therapeutic target. HNSCC is not characterized by frequent kinase mutations, in contrast to some malignancies where mutational activation of kinases ups...

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Detalles Bibliográficos
Autores principales: Peyser, Noah D., Freilino, Maria, Wang, Lin, Zeng, Yan, Li, Hua, Johnson, Daniel E., Grandis, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651851/
https://www.ncbi.nlm.nih.gov/pubmed/25982282
http://dx.doi.org/10.1038/onc.2015.171

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