Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model

Murine tumor models that closely reflect human diseases are important tools to investigate carcinogenesis and tumor immunity. The transgenic (tg) mouse strain tg(Grm1)EPv develops spontaneous melanoma due to ectopic overexpression of the metabotropic glutamate receptor 1 (Grm1) in melanocytes. In th...

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Detalles Bibliográficos
Autores principales: Mairhofer, David G, Ortner, Daniela, Tripp, Christoph H, Schaffenrath, Sandra, Fleming, Viktor, Heger, Lukas, Komenda, Kerstin, Reider, Daniela, Dudziak, Diana, Chen, Suzie, Becker, Jürgen C, Flacher, Vincent, Stoitzner, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652066/
https://www.ncbi.nlm.nih.gov/pubmed/26121214
http://dx.doi.org/10.1038/jid.2015.241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652066/
https://www.ncbi.nlm.nih.gov/pubmed/26121214
http://dx.doi.org/10.1038/jid.2015.241

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