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Impaired gp100-Specific CD8(+) T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model
Murine tumor models that closely reflect human diseases are important tools to investigate carcinogenesis and tumor immunity. The transgenic (tg) mouse strain tg(Grm1)EPv develops spontaneous melanoma due to ectopic overexpression of the metabotropic glutamate receptor 1 (Grm1) in melanocytes. In th...
Autores principales: | Mairhofer, David G, Ortner, Daniela, Tripp, Christoph H, Schaffenrath, Sandra, Fleming, Viktor, Heger, Lukas, Komenda, Kerstin, Reider, Daniela, Dudziak, Diana, Chen, Suzie, Becker, Jürgen C, Flacher, Vincent, Stoitzner, Patrizia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652066/ https://www.ncbi.nlm.nih.gov/pubmed/26121214 http://dx.doi.org/10.1038/jid.2015.241 |
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