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The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites

(18)F-fluoromisonidazole (FMISO) has been widely used as a hypoxia imaging probe for diagnostic positron emission tomography (PET). FMISO is believed to accumulate in hypoxic cells via covalent binding with macromolecules after reduction of its nitro group. However, its detailed accumulation mechani...

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Detalles Bibliográficos
Autores principales:	Masaki, Yukiko, Shimizu, Yoichi, Yoshioka, Takeshi, Tanaka, Yukari, Nishijima, Ken-ichi, Zhao, Songji, Higashino, Kenichi, Sakamoto, Shingo, Numata, Yoshito, Yamaguchi, Yoshitaka, Tamaki, Nagara, Kuge, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652161/ https://www.ncbi.nlm.nih.gov/pubmed/26582591 http://dx.doi.org/10.1038/srep16802

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