Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome

In addition to its role in sister chromatid cohesion, genome stability and integrity, the cohesin complex is involved in gene transcription. Mutations in core cohesin subunits SMC1A, SMC3 and RAD21, or their regulators NIPBL and HDAC8, cause Cornelia de Lange syndrome (CdLS). Recent evidence reveals...

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Detalles Bibliográficos
Autores principales: Mannini, Linda, C. Lamaze, Fabien, Cucco, Francesco, Amato, Clelia, Quarantotti, Valentina, Rizzo, Ilaria M, Krantz, Ian D, Bilodeau, Steve, Musio, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652179/
https://www.ncbi.nlm.nih.gov/pubmed/26581180
http://dx.doi.org/10.1038/srep16803

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