Dual transcriptome sequencing reveals resistance of TLR4 ligand-activated bone marrow-derived macrophages to inflammation mediated by the BET inhibitor JQ1

Persistent macrophage activation is associated with the expression of various pro-inflammatory genes, cytokines and chemokines, which may initiate or amplify inflammatory disorders. A novel synthetic BET inhibitor, JQ1, was proven to exert immunosuppressive activities in macrophages. However, a geno...

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Detalles Bibliográficos
Autores principales: Das, Amitabh, Chai, Jin Choul, Yang, Chul-su, Lee, Young Seek, Das, Nando Dulal, Jung, Kyoung Hwa, Chai, Young Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652239/
https://www.ncbi.nlm.nih.gov/pubmed/26582142
http://dx.doi.org/10.1038/srep16932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652239/
https://www.ncbi.nlm.nih.gov/pubmed/26582142
http://dx.doi.org/10.1038/srep16932

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