Cargando…
CMV promoter mutants with a reduced propensity to productivity loss in CHO cells
The major immediate-early promoter and enhancer of the human cytomegalovirus (hCMV-MIE) is one of the most potent DNA elements driving recombinant gene expression in mammalian cells. Therefore, it is widely employed not only in research but also in large-scale industrial applications, e.g. for the p...
Autores principales: | Moritz, Benjamin, Becker, Peter B., Göpfert, Ulrich |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652263/ https://www.ncbi.nlm.nih.gov/pubmed/26581326 http://dx.doi.org/10.1038/srep16952 |
Ejemplares similares
-
Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody
por: Dahodwala, Hussain, et al.
Publicado: (2022) -
Evaluating the efficiency of CHEF and CMV promoter with IRES and Furin/2A linker sequences for monoclonal antibody expression in CHO cells
por: Ebadat, Saeedeh, et al.
Publicado: (2017) -
Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection
por: Dobbins, G. Clement, et al.
Publicado: (2019) -
Correction to: Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection
por: Dobbins, G. Clement, et al.
Publicado: (2020) -
Impact on product quality of high productive GS-CHO cell lines
por: Perani, Angelo, et al.
Publicado: (2011)