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Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis

BACKGROUND: In experimental autoimmune encephalomyelitis (EAE), deletion of transient receptor potential melastatin 4 (Trpm4) and administration of glibenclamide were found to ameliorate disease progression, prompting speculation that glibenclamide acts by directly inhibiting Trpm4. We hypothesized...

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Detalles Bibliográficos
Autores principales:	Makar, Tapas K., Gerzanich, Volodymyr, Nimmagadda, Vamshi K.C., Jain, Rupal, Lam, Kristal, Mubariz, Fahad, Trisler, David, Ivanova, Svetlana, Woo, Seung Kyoon, Kwon, Min Seong, Bryan, Joseph, Bever, Christopher T., Simard, J. Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652344/ https://www.ncbi.nlm.nih.gov/pubmed/26581714 http://dx.doi.org/10.1186/s12974-015-0432-3

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