Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia and scoliosis. These analyses have however been...

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Detalles Bibliográficos
Autores principales: Javaheri, B., Carriero, A., Staines, K.A., Chang, Y.-M., Houston, D.A., Oldknow, K.J., Millan, J.L., Kazeruni, Bassir N., Salmon, P., Shefelbine, S., Farquharson, C., Pitsillides, A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Original Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652607/
https://www.ncbi.nlm.nih.gov/pubmed/26232374
http://dx.doi.org/10.1016/j.bone.2015.07.035

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