SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells

Recent studies have shown that homologous recombination (HR) requires chromatin repression as well as relaxation at DNA double strand breaks (DSBs). HP1 and SUV39H1/2 are repressive factors essential for HR. Here, we identify SETDB1 as an additional compacting factor promoting HR. Depletion of HP1,...

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Detalles Bibliográficos
Autores principales: Alagoz, Meryem, Katsuki, Yoko, Ogiwara, Hideaki, Ogi, Tomoo, Shibata, Atsushi, Kakarougkas, Andreas, Jeggo, Penny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652757/
https://www.ncbi.nlm.nih.gov/pubmed/26206670
http://dx.doi.org/10.1093/nar/gkv722

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