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Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
Due to their high affinity and specificity, aptamers have been widely used as effective inhibitors in clinical applications. However, the ability to activate protein function through aptamer-protein interaction has not been well-elucidated. To investigate their potential as target-specific agonists,...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652772/ https://www.ncbi.nlm.nih.gov/pubmed/26245346 http://dx.doi.org/10.1093/nar/gkv767 |