Cargando…
Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods
A solution containing (68)Ge in equilibrium with its daughter, (68)Ga, has been standardized for the first time at the National Institute of Standards and Technology (NIST) using 3 liquid scintillation-based techniques: live-timed 4πβ -γ anticoincidence (LTAC) counting, the Triple-to-Double Coincide...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
[Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652876/ https://www.ncbi.nlm.nih.gov/pubmed/27096126 http://dx.doi.org/10.6028/jres.113.020 |
_version_ | 1782401832448950272 |
---|---|
author | Zimmerman, B. E. Cessna, J. T. Fitzgerald, R. |
author_facet | Zimmerman, B. E. Cessna, J. T. Fitzgerald, R. |
author_sort | Zimmerman, B. E. |
collection | PubMed |
description | A solution containing (68)Ge in equilibrium with its daughter, (68)Ga, has been standardized for the first time at the National Institute of Standards and Technology (NIST) using 3 liquid scintillation-based techniques: live-timed 4πβ -γ anticoincidence (LTAC) counting, the Triple-to-Double Coincidence Ratio (TDCR) method, and (3)H-standard efficiency tracing with the CIEMAT(1)/NIST (CNET) method. The LTAC technique is much less dependent on level scheme data and model-dependent parameters and was thus able to provide a reference activity concentration value for the master solution with a combined standard uncertainty of about 0.3 %. The other two methods gave activity concentration values with respective differences from the reference value of +1.2 % and −1.5 %, which were still within the experimental uncertainties. Measurements made on the NIST “4π”γ secondary standard ionization chamber allowed for the determination of calibration factors for that instrument, allowing future calibrations to be made for (68)Ge/(68)Ga without the need for a primary measurement. The ability to produce standardized solutions of (68)Ge presents opportunities for the development of a number of NIST-traceable calibration sources with very low (<1 %) relative standard uncertainties that can be used in diagnostic medical imaging. |
format | Online Article Text |
id | pubmed-4652876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology |
record_format | MEDLINE/PubMed |
spelling | pubmed-46528762016-04-19 Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods Zimmerman, B. E. Cessna, J. T. Fitzgerald, R. J Res Natl Inst Stand Technol Article A solution containing (68)Ge in equilibrium with its daughter, (68)Ga, has been standardized for the first time at the National Institute of Standards and Technology (NIST) using 3 liquid scintillation-based techniques: live-timed 4πβ -γ anticoincidence (LTAC) counting, the Triple-to-Double Coincidence Ratio (TDCR) method, and (3)H-standard efficiency tracing with the CIEMAT(1)/NIST (CNET) method. The LTAC technique is much less dependent on level scheme data and model-dependent parameters and was thus able to provide a reference activity concentration value for the master solution with a combined standard uncertainty of about 0.3 %. The other two methods gave activity concentration values with respective differences from the reference value of +1.2 % and −1.5 %, which were still within the experimental uncertainties. Measurements made on the NIST “4π”γ secondary standard ionization chamber allowed for the determination of calibration factors for that instrument, allowing future calibrations to be made for (68)Ge/(68)Ga without the need for a primary measurement. The ability to produce standardized solutions of (68)Ge presents opportunities for the development of a number of NIST-traceable calibration sources with very low (<1 %) relative standard uncertainties that can be used in diagnostic medical imaging. [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology 2008 2008-10-01 /pmc/articles/PMC4652876/ /pubmed/27096126 http://dx.doi.org/10.6028/jres.113.020 Text en https://creativecommons.org/publicdomain/zero/1.0/ The Journal of Research of the National Institute of Standards and Technology is a publication of the U.S. Government. The papers are in the public domain and are not subject to copyright in the United States. Articles from J Res may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Article Zimmerman, B. E. Cessna, J. T. Fitzgerald, R. Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods |
title | Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods |
title_full | Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods |
title_fullStr | Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods |
title_full_unstemmed | Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods |
title_short | Standardization of (68)Ge/(68)Ga Using Three Liquid Scintillation Counting Based Methods |
title_sort | standardization of (68)ge/(68)ga using three liquid scintillation counting based methods |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652876/ https://www.ncbi.nlm.nih.gov/pubmed/27096126 http://dx.doi.org/10.6028/jres.113.020 |
work_keys_str_mv | AT zimmermanbe standardizationof68ge68gausingthreeliquidscintillationcountingbasedmethods AT cessnajt standardizationof68ge68gausingthreeliquidscintillationcountingbasedmethods AT fitzgeraldr standardizationof68ge68gausingthreeliquidscintillationcountingbasedmethods |