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GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell growth. Herein, we demonstrate that suppressing...

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Detalles Bibliográficos
Autores principales:	Stretton, Clare, Hoffmann, Thorsten M., Munson, Michael J., Prescott, Alan, Taylor, Peter M., Ganley, Ian G., Hundal, Harinder S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652938/ https://www.ncbi.nlm.nih.gov/pubmed/26348909 http://dx.doi.org/10.1042/BJ20150404

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