Clinical next generation sequencing to identify actionable aberrations in a phase I program

PURPOSE: We determined the frequency of recurrent hotspot mutations in 46 cancer-related genes across tumor histologies in patients with advanced cancer. METHODS: We reviewed data from 500 consecutive patients who underwent genomic profiling on an IRB-approved prospective clinical protocol in the Ph...

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Detalles Bibliográficos
Autores principales: Boland, Genevieve M., Piha-Paul, Sarina A., Subbiah, Vivek, Routbort, Mark, Herbrich, Shelley M., Baggerly, Keith, Patel, Keyur P., Brusco, Lauren, Horombe, Chacha, Naing, Aung, Fu, Siqing, Hong, David S., Janku, Filip, Johnson, Amber, Broaddus, Russell, Luthra, Raja, Shaw, Kenna, Mendelsohn, John, Mills, Gordon B., Meric-Bernstam, Funda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652990/
https://www.ncbi.nlm.nih.gov/pubmed/26015395

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