FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro

Myxoid liposarcomas account for more than one third of liposarcomas and about 10% of all adult soft tissue sarcomas. The tumors are characterized by specific chromosomal translocations leading to the chimeric oncogenes FUS-DDIT3 or EWS1R-DDIT3. The encoded fusion proteins act as aberrant transcripti...

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Detalles Bibliográficos
Autores principales: Künstlinger, Helen, Fassunke, Jana, Schildhaus, Hans-Ulrich, Brors, Benedikt, Heydt, Carina, Ihle, Michaela Angelika, Mechtersheimer, Gunhild, Wardelmann, Eva, Büttner, Reinhard, Merkelbach-Bruse, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652999/
https://www.ncbi.nlm.nih.gov/pubmed/26036639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652999/
https://www.ncbi.nlm.nih.gov/pubmed/26036639

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