Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma

Mice sensitized to ovalbumin (OVA) develop allergic airway disease (AAD) with short-term daily OVA aerosol challenge; inflammation resolves with long-term OVA aerosol exposure, resulting in local inhalational tolerance (LIT). Cbl-b is an E3 ubiquitin ligase involved with CD28 signaling; Cbl-b(−/−) e...

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Detalles Bibliográficos
Autores principales: Carson, William F., Guernsey, Linda A., Singh, Anurag, Secor, Eric R., Wohlfert, Elizabeth A., Clark, Robert B., Schramm, Craig M., Kunkel, Steven L., Thrall, Roger S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653292/
https://www.ncbi.nlm.nih.gov/pubmed/26635806
http://dx.doi.org/10.3389/fimmu.2015.00592

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