Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose–response data

Motivation: Most data analysis tools for high-throughput screening (HTS) seek to uncover interesting hits for further analysis. They typically assume a low hit rate per plate. Hit rates can be dramatically higher in secondary screening, RNAi screening and in drug sensitivity testing using biological...

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Detalles Bibliográficos
Autores principales: Mpindi, John-Patrick, Swapnil, Potdar, Dmitrii, Bychkov, Jani, Saarela, Saeed, Khalid, Wennerberg, Krister, Aittokallio, Tero, Östling, Päivi, Kallioniemi, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653387/
https://www.ncbi.nlm.nih.gov/pubmed/26254433
http://dx.doi.org/10.1093/bioinformatics/btv455

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