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Disposable optics for microscopy diagnostics

The point-of-care testing (POCT) is having increasing role on modern health care systems due to a possibility to perform tests for patients conveniently and immediately. POCT includes lot of disposable devices because of the environment they are often used. For a disposable system to be reasonably u...

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Autores principales: Vilmi, Pauliina, Varjo, Sami, Sliz, Rafal, Hannuksela, Jari, Fabritius, Tapio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653661/
https://www.ncbi.nlm.nih.gov/pubmed/26586153
http://dx.doi.org/10.1038/srep16957
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author Vilmi, Pauliina
Varjo, Sami
Sliz, Rafal
Hannuksela, Jari
Fabritius, Tapio
author_facet Vilmi, Pauliina
Varjo, Sami
Sliz, Rafal
Hannuksela, Jari
Fabritius, Tapio
author_sort Vilmi, Pauliina
collection PubMed
description The point-of-care testing (POCT) is having increasing role on modern health care systems due to a possibility to perform tests for patients conveniently and immediately. POCT includes lot of disposable devices because of the environment they are often used. For a disposable system to be reasonably utilized, it needs to be high in quality but low in price. Optics based POCT systems are interesting approach to be developed, and here we describe a low-cost fabrication process for microlens arrays for microscopy. Lens arrays having average lens diameter of 222 μm with 300 μm lens pitch were fabricated. The lenses were characterized to have standard deviation of 0.06 μm in height and 4.61 μm in diameter. The resolution limit of 3.9μm is demonstrated with real images, and the images were compared with ones made with glass and polycarbonate lens arrays. The image quality is at the same level than with the glass lenses and the manufacturing costs are very low, thus making them suitable for POCT applications.
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spelling pubmed-46536612015-11-25 Disposable optics for microscopy diagnostics Vilmi, Pauliina Varjo, Sami Sliz, Rafal Hannuksela, Jari Fabritius, Tapio Sci Rep Article The point-of-care testing (POCT) is having increasing role on modern health care systems due to a possibility to perform tests for patients conveniently and immediately. POCT includes lot of disposable devices because of the environment they are often used. For a disposable system to be reasonably utilized, it needs to be high in quality but low in price. Optics based POCT systems are interesting approach to be developed, and here we describe a low-cost fabrication process for microlens arrays for microscopy. Lens arrays having average lens diameter of 222 μm with 300 μm lens pitch were fabricated. The lenses were characterized to have standard deviation of 0.06 μm in height and 4.61 μm in diameter. The resolution limit of 3.9μm is demonstrated with real images, and the images were compared with ones made with glass and polycarbonate lens arrays. The image quality is at the same level than with the glass lenses and the manufacturing costs are very low, thus making them suitable for POCT applications. Nature Publishing Group 2015-11-20 /pmc/articles/PMC4653661/ /pubmed/26586153 http://dx.doi.org/10.1038/srep16957 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Vilmi, Pauliina
Varjo, Sami
Sliz, Rafal
Hannuksela, Jari
Fabritius, Tapio
Disposable optics for microscopy diagnostics
title Disposable optics for microscopy diagnostics
title_full Disposable optics for microscopy diagnostics
title_fullStr Disposable optics for microscopy diagnostics
title_full_unstemmed Disposable optics for microscopy diagnostics
title_short Disposable optics for microscopy diagnostics
title_sort disposable optics for microscopy diagnostics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653661/
https://www.ncbi.nlm.nih.gov/pubmed/26586153
http://dx.doi.org/10.1038/srep16957
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AT fabritiustapio disposableopticsformicroscopydiagnostics