COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)

Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzym...

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Detalles Bibliográficos
Autores principales: Muhammad, Aminu, Sirat, Hasnah Mohd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653721/
https://www.ncbi.nlm.nih.gov/pubmed/26600739
Descripción
Sumario:Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 µM (IC(50) 0.46 µM) compared to the positive control, indomethacin (79.20 %, IC(50) 0.24 µM).

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