COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)

Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzym...

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Detalles Bibliográficos
Autores principales: Muhammad, Aminu, Sirat, Hasnah Mohd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653721/
https://www.ncbi.nlm.nih.gov/pubmed/26600739
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author Muhammad, Aminu
Sirat, Hasnah Mohd
author_facet Muhammad, Aminu
Sirat, Hasnah Mohd
author_sort Muhammad, Aminu
collection PubMed
description Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 µM (IC(50) 0.46 µM) compared to the positive control, indomethacin (79.20 %, IC(50) 0.24 µM).
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spelling pubmed-46537212015-11-23 COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae) Muhammad, Aminu Sirat, Hasnah Mohd EXCLI J Original Article Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 µM (IC(50) 0.46 µM) compared to the positive control, indomethacin (79.20 %, IC(50) 0.24 µM). Leibniz Research Centre for Working Environment and Human Factors 2013-09-13 /pmc/articles/PMC4653721/ /pubmed/26600739 Text en Copyright © 2013 Muhammad et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Muhammad, Aminu
Sirat, Hasnah Mohd
COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
title COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
title_full COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
title_fullStr COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
title_full_unstemmed COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
title_short COX-2 inhibitors from stem bark of Bauhinia rufescens Lam. (Fabaceae)
title_sort cox-2 inhibitors from stem bark of bauhinia rufescens lam. (fabaceae)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653721/
https://www.ncbi.nlm.nih.gov/pubmed/26600739
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