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Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP(2)-Regulated Dynamics of the N-Terminus

[Image: see text] We present the dynamic mechanism of concerted motions in a full-length molecular model of the human dopamine transporter (hDAT), a member of the neurotransmitter/sodium symporter (NSS) family, involved in state-to-state transitions underlying function. The findings result from an a...

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Detalles Bibliográficos
Autores principales:	Khelashvili, George, Stanley, Nathaniel, Sahai, Michelle A., Medina, Jaime, LeVine, Michael V., Shi, Lei, De Fabritiis, Gianni, Weinstein, Harel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653762/ https://www.ncbi.nlm.nih.gov/pubmed/26255829 http://dx.doi.org/10.1021/acschemneuro.5b00179

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