Cargando…

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

[Image: see text] Numerous clinical and preclinical studies have suggested several health promoting effects for the dietary consumption of extra-virgin olive oil (EVOO) that could protect and decrease the risk of developing Alzheimer’s disease (AD). Moreover, recent studies have linked this protecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qosa, Hisham, Batarseh, Yazan S., Mohyeldin, Mohamed M., El Sayed, Khalid A., Keller, Jeffrey N., Kaddoumi, Amal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653763/ https://www.ncbi.nlm.nih.gov/pubmed/26348065 http://dx.doi.org/10.1021/acschemneuro.5b00190

Ejemplares similares

Blood-Brain Barrier Disruption Increases Amyloid-Related Pathology in TgSwDI Mice
por: Abdallah, Ihab M., et al.
Publicado: (2021)

Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models
por: Goñi, Fernando, et al.
Publicado: (2013)

Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity
por: Siddique, Abu Bakar, et al.
Publicado: (2019)

Comparison of Oleocanthal-Low EVOO and Oleocanthal against Amyloid-β and Related Pathology in a Mouse Model of Alzheimer’s Disease
por: Abdallah, Ihab M., et al.
Publicado: (2023)

The Blood–Brain Barrier in Health and Disease
por: Al Rihani, Sweilem B., et al.
Publicado: (2023)

Comment on López-Yerena et al. “Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats” Pharmaceutics 2020, 12, 134
por: Kaddoumi, Amal, et al.
Publicado: (2020)

Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders
por: Batarseh, Yazan S., et al.
Publicado: (2016)

Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer’s Disease
por: Yang, Euitaek, et al.
Publicado: (2023)

The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor
por: Mohyeldin, Mohamed M., et al.
Publicado: (2016)

Impact of Age on the Cerebrovascular Proteomes of Wild-Type and Tg-SwDI Mice
por: Searcy, James L., et al.
Publicado: (2014)

Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy
por: Robison, Lisa S., et al.
Publicado: (2019)

Olive Phenolics as c-Met Inhibitors: (-)-Oleocanthal Attenuates Cell Proliferation, Invasiveness, and Tumor Growth in Breast Cancer Models
por: Akl, Mohamed R., et al.
Publicado: (2014)

(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells
por: Goren, Limor, et al.
Publicado: (2019)

(−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo
por: Siddique, Abu Bakar, et al.
Publicado: (2019)

S-(−)-Oleocanthal Ex Vivo Modulatory Effects on Gut Microbiota
por: Qusa, Mohammed H., et al.
Publicado: (2023)

Plasma Rich in Growth Factors (PRGF) Disrupt the Blood-Brain Barrier Integrity and Elevate Amyloid Pathology in the Brains of 5XFAD Mice
por: Duong, Quoc-Viet, et al.
Publicado: (2019)

Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer’s model
por: Hanafy, Amira Sayed, et al.
Publicado: (2023)

Scalable and DiI-compatible optical clearance of the mammalian brain
por: Hou, Bing, et al.
Publicado: (2015)

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain
por: Heiland, Tina, et al.
Publicado: (2018)

Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
por: Li, Yi, et al.
Publicado: (2022)

Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats
por: López-Yerena, Anallely, et al.
Publicado: (2020)

(-)-Oleocanthal Nutraceuticals for Alzheimer’s Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model
por: Tajmim, Afsana, et al.
Publicado: (2021)

Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice
por: Honarpisheh, Pedram, et al.
Publicado: (2020)

Safety Evaluations of Single Dose of the Olive Secoiridoid S-(−)-Oleocanthal in Swiss Albino Mice
por: Siddique, Abu Bakar, et al.
Publicado: (2020)

A Simulation Model of Periarterial Clearance of Amyloid-β from the Brain
por: Diem, Alexandra K., et al.
Publicado: (2016)

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier
por: Keaney, James, et al.
Publicado: (2015)

Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases
por: Ullah, Rahat, et al.
Publicado: (2023)

The Biological Activities of Oleocanthal from a Molecular Perspective
por: Pang, Kok-Lun, et al.
Publicado: (2018)

(−)-Methyl-Oleocanthal, a New Oleocanthal Metabolite Reduces LPS-Induced Inflammatory and Oxidative Response: Molecular Signaling Pathways and Histones Epigenetic Modulation
por: Montoya, Tatiana, et al.
Publicado: (2021)

The Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate Affects the Differentiation of Human Liposarcoma Cells (SW 872)
por: Campioli, Enrico, et al.
Publicado: (2011)

Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance
por: Zhao, Zhen, et al.
Publicado: (2015)

(−)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer
por: Siddique, Abu Bakar, et al.
Publicado: (2020)

Optimization of Taste-Masked (–)-Oleocanthal Effervescent Formulation with Potent Breast Cancer Progression and Recurrence Suppressive Activities
por: Tajmim, Afsana, et al.
Publicado: (2019)

Current Disease-Targets for Oleocanthal as Promising Natural Therapeutic Agent
por: Segura-Carretero, Antonio, et al.
Publicado: (2018)

Exploring the Immunotherapeutic Potential of Oleocanthal against Murine Cutaneous Leishmaniasis
por: Karampetsou, Kalliopi, et al.
Publicado: (2022)

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice
por: Kang, ShinWoo, et al.
Publicado: (2022)

Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2
por: Siddique, Abu Bakar, et al.
Publicado: (2022)

Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy
por: Zhu, Xiaoyue, et al.
Publicado: (2020)

Correction: Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ubefgfs2g7pbvhkbnh1kt40ja5