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Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

BACKGROUND: Colorectal cancer is the third most common malignancy in humans and novel therapeutic approaches are urgently needed. Autophagy is an evolutionarily highly conserved cellular process by which cells collect unnecessary organelles or misfolded proteins and subsequently degrade them in vesi...

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Detalles Bibliográficos
Autores principales:	Koehler, Bruno Christian, Jassowicz, Adam, Scherr, Anna-Lena, Lorenz, Stephan, Radhakrishnan, Praveen, Kautz, Nicole, Elssner, Christin, Weiss, Johanna, Jaeger, Dirk, Schneider, Martin, Schulze-Bergkamen, Henning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653869/ https://www.ncbi.nlm.nih.gov/pubmed/26585594 http://dx.doi.org/10.1186/s12885-015-1929-y

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