Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and recruitment of cytoplasmic signaling proteins. Although the exact mechanism of CD28 signal transductio...

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Detalles Bibliográficos
Autores principales: Lim, Hong-Sheng, Cordoba, Shaun-Paul, Dushek, Omer, Goyette, Jesse, Taylor, Alison, Rudd, Christopher E., van der Merwe, P. Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2015
Materias:
Molecular and Structural Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654228/
https://www.ncbi.nlm.nih.gov/pubmed/26500347
http://dx.doi.org/10.4049/jimmunol.1500707

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