Cargando…

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA

Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells. While F(ab′)(2) portions of DSA cause cellular activation and proliferation,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, K A, Valenzuela, N M, Gjertson, D, Mulder, A, Fishbein, M C, Parry, G C, Panicker, S, Reed, E F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654252/ https://www.ncbi.nlm.nih.gov/pubmed/25904443 http://dx.doi.org/10.1111/ajt.13273

Ejemplares similares

Complement-Mediated Enhancement of Monocyte Adhesion to Endothelial Cells by HLA Antibodies, and Blockade by a Specific Inhibitor of the Classical Complement Cascade, TNT003
por: Valenzuela, Nicole M., et al.
Publicado: (2017)

Effect of the Anti‐C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody–Induced Complement Activation—A Preclinical In Vitro Study
por: Wahrmann, M., et al.
Publicado: (2017)

Blockade of HLA Antibody-Triggered Classical Complement Activation in Sera From Subjects Dosed With the Anti-C1s Monoclonal Antibody TNT009—Results from a Randomized First-in-Human Phase 1 Trial
por: Mühlbacher, Jakob, et al.
Publicado: (2017)

Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation
por: Muñoz-Herrera, Claudia M., et al.
Publicado: (2023)

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets
por: Rijkers, Maaike, et al.
Publicado: (2019)

Complement-dependent cytotoxicity of anti-human osteogenic sarcoma monoclonal antibodies.
por: Price, M. R., et al.
Publicado: (1982)

Cytotoxicity of TNT and its metabolites.
por: Banerjee, H. N., et al.
Publicado: (1999)

Bioremediation of Explosive TNT by Trichoderma viride
por: Alothman, Zeid A., et al.
Publicado: (2020)

A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat
por: Keith, James C, et al.
Publicado: (2005)

Detection of TNT-derivatives with recombinant phages
por: Simonovicá, Mladen, et al.
Publicado: (2012)

Development and characterization of novel anti‐C5 monoclonal antibodies capable of inhibiting complement in multiple species
por: Zelek, Wioleta M., et al.
Publicado: (2019)

Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis
por: Bouquegneau, Antoine, et al.
Publicado: (2018)

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody
por: Gulati, Sunita, et al.
Publicado: (2019)

Complement-Binding Donor-Specific Anti-HLA Antibodies: Biomarker for Immunologic Risk Stratification in Pediatric Kidney Transplantation Recipients
por: Sigurjonsdottir, Vaka K., et al.
Publicado: (2022)

HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes
por: Bezstarosti, Suzanne, et al.
Publicado: (2022)

Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies
Publicado: (1991)

In vivo inhibition of the antibody response by a complement receptor- specific monoclonal antibody
Publicado: (1990)

Correction: Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis
por: Bouquegneau, Antoine, et al.
Publicado: (2018)

TnT: T Antigen and Telomerase, an Explosive Route to Cancer
por: Ray, F. Andrew
Publicado: (2008)

TNT in rectal cancer may not be the new testament?
por: Glynne-Jones, Rob
Publicado: (2019)

Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA‐DR
por: Kramer, Cynthia S. M., et al.
Publicado: (2020)

Monoclonal Antibodies Capable of Inhibiting Complement Downstream of C5 in Multiple Species
por: Zelek, Wioleta M., et al.
Publicado: (2020)

Monoclonal antibodies effectively potentiate complement activation and phagocytosis of Staphylococcus epidermidis in neonatal human plasma
por: de Vor, Lisanne, et al.
Publicado: (2022)

Studies of Limit of Detection on 2,4,6-Trinitrotoluene (TNT) by Mass Spectrometry
por: Lee, M. R., et al.
Publicado: (1988)

Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer
por: Meyer, Saskia, et al.
Publicado: (2014)

Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines
por: Prang, N, et al.
Publicado: (2005)

Vascular and Non-HLA autoantibody profiles in hospitalized patients with COVID-19
por: Lichtenstein, Brian, et al.
Publicado: (2023)

P1303: POTENTIATING ANTI-CD20 MONOCLONAL ANTIBODY THERAPY BY TARGETING COMPLEMENT C3 ACTIVATION FRAGMENTS COVALENTLY DEPOSITED ON LYMPHOMA CELLS
por: Wiestner, A., et al.
Publicado: (2022)

Nonisothermal decomposition and safety parameters of HNIW/TNT cocrystal
por: Zhang, Jiao-Qiang, et al.
Publicado: (2018)

Anti-infective monoclonal antibodies: perils and promise of development
por: Reichert, Janice M., et al.
Publicado: (2006)

Radiation of the Tnt1 retrotransposon superfamily in three Solanaceae genera
por: Manetti, Maria E, et al.
Publicado: (2007)

Anti-GRP-R monoclonal antibody antitumor therapy against neuroblastoma
por: Qiao, Jingbo, et al.
Publicado: (2022)

Immunogenicity of Monoclonal Antibodies and the Potential Use of HLA Haplotypes to Predict Vulnerable Patients
por: Mosch, Romy, et al.
Publicado: (2022)

Plasma-Modified, Epitaxial Fabricated Graphene on SiC for the Electrochemical Detection of TNT
por: Trammell, Scott A., et al.
Publicado: (2016)

Ramifications of the HLA-I Allelic Reactivity of Anti-HLA-E*01:01 and Anti-HLA-E*01:03 Heavy Chain Monoclonal Antibodies in Comparison with Anti-HLA-I IgG Reactivity in Non-Alloimmunized Males, Melanoma-Vaccine Recipients, and End-Stage Renal Disease Patients
por: Ravindranath, Mepur H., et al.
Publicado: (2022)

Human monoclonal antibodies and monoclonal antibody multispecificity.
por: Campbell, A. M., et al.
Publicado: (1987)

In vivo effects of monoclonal antibodies that functionally inhibit complement regulatory proteins in rats
Publicado: (1994)

Integrating Paper Chromatography with Electrochemical Detection for the Trace Analysis of TNT in Soil
por: Ryan, Patrick, et al.
Publicado: (2015)

The Tnt1 Retrotransposon Escapes Silencing in Tobacco, Its Natural Host
por: Hernández-Pinzón, Inmaculada, et al.
Publicado: (2012)

Complement-activating donor-specific anti-HLA antibodies in solid organ transplantation: systematic review, meta-analysis, and critical appraisal
por: Al-Awadhi, Solaf, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v6qbp4u7l81hc0gkckpv0njch6