Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinati...

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Detalles Bibliográficos
Autores principales: Mellerup, Erling, Andreassen, Ole A., Bennike, Bente, Dam, Henrik, Djurovic, Srdjan, Hansen, Thomas, Jorgensen, Martin Balslev, Kessing, Lars Vedel, Koefoed, Pernille, Melle, Ingrid, Mors, Ole, Werge, Thomas, Moeller, Gert Lykke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654514/
https://www.ncbi.nlm.nih.gov/pubmed/26587987
http://dx.doi.org/10.1371/journal.pone.0143432
Descripción
Sumario:The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.

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