Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinati...

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Autores principales: Mellerup, Erling, Andreassen, Ole A., Bennike, Bente, Dam, Henrik, Djurovic, Srdjan, Hansen, Thomas, Jorgensen, Martin Balslev, Kessing, Lars Vedel, Koefoed, Pernille, Melle, Ingrid, Mors, Ole, Werge, Thomas, Moeller, Gert Lykke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654514/
https://www.ncbi.nlm.nih.gov/pubmed/26587987
http://dx.doi.org/10.1371/journal.pone.0143432
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author Mellerup, Erling
Andreassen, Ole A.
Bennike, Bente
Dam, Henrik
Djurovic, Srdjan
Hansen, Thomas
Jorgensen, Martin Balslev
Kessing, Lars Vedel
Koefoed, Pernille
Melle, Ingrid
Mors, Ole
Werge, Thomas
Moeller, Gert Lykke
author_facet Mellerup, Erling
Andreassen, Ole A.
Bennike, Bente
Dam, Henrik
Djurovic, Srdjan
Hansen, Thomas
Jorgensen, Martin Balslev
Kessing, Lars Vedel
Koefoed, Pernille
Melle, Ingrid
Mors, Ole
Werge, Thomas
Moeller, Gert Lykke
author_sort Mellerup, Erling
collection PubMed
description The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.
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spelling pubmed-46545142015-11-25 Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons Mellerup, Erling Andreassen, Ole A. Bennike, Bente Dam, Henrik Djurovic, Srdjan Hansen, Thomas Jorgensen, Martin Balslev Kessing, Lars Vedel Koefoed, Pernille Melle, Ingrid Mors, Ole Werge, Thomas Moeller, Gert Lykke PLoS One Research Article The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome. Public Library of Science 2015-11-20 /pmc/articles/PMC4654514/ /pubmed/26587987 http://dx.doi.org/10.1371/journal.pone.0143432 Text en © 2015 Mellerup et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Mellerup, Erling
Andreassen, Ole A.
Bennike, Bente
Dam, Henrik
Djurovic, Srdjan
Hansen, Thomas
Jorgensen, Martin Balslev
Kessing, Lars Vedel
Koefoed, Pernille
Melle, Ingrid
Mors, Ole
Werge, Thomas
Moeller, Gert Lykke
Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons
title Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons
title_full Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons
title_fullStr Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons
title_full_unstemmed Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons
title_short Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons
title_sort combinations of genetic data present in bipolar patients, but absent in control persons
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654514/
https://www.ncbi.nlm.nih.gov/pubmed/26587987
http://dx.doi.org/10.1371/journal.pone.0143432
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