Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1)

Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by cytochrome b5. How this is achie...

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Detalles Bibliográficos
Autores principales: Simonov, Alexandr N., Holien, Jessica K., Yeung, Joyee Chun In, Nguyen, Ann D., Corbin, C. Jo, Zheng, Jie, Kuznetsov, Vladimir L., Auchus, Richard J., Conley, Alan J., Bond, Alan M., Parker, Michael W., Rodgers, Raymond J., Martin, Lisandra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654539/
https://www.ncbi.nlm.nih.gov/pubmed/26587646
http://dx.doi.org/10.1371/journal.pone.0141252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654539/
https://www.ncbi.nlm.nih.gov/pubmed/26587646
http://dx.doi.org/10.1371/journal.pone.0141252

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