A Dual Model for Prioritizing Cancer Mutations in the Non-coding Genome Based on Germline and Somatic Events

We address here the issue of prioritizing non-coding mutations in the tumoral genome. To this aim, we created two independent computational models. The first (germline) model estimates purifying selection based on population SNP data. The second (somatic) model estimates tumor mutation density based...

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Detalles Bibliográficos
Autores principales: Li, Jia, Poursat, Marie-Anne, Drubay, Damien, Motz, Arnaud, Saci, Zohra, Morillon, Antonin, Michiels, Stefan, Gautheret, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654583/
https://www.ncbi.nlm.nih.gov/pubmed/26588488
http://dx.doi.org/10.1371/journal.pcbi.1004583

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