Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

Arenaviruses such as Lassa virus (LASV) can cause severe hemorrhagic fever in humans. As a major impediment to vaccine development, delayed and weak neutralizing antibody (nAb) responses represent a unifying characteristic of both natural infection and all vaccine candidates tested to date. To inves...

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Detalles Bibliográficos
Autores principales: Sommerstein, Rami, Flatz, Lukas, Remy, Melissa M., Malinge, Pauline, Magistrelli, Giovanni, Fischer, Nicolas, Sahin, Mehmet, Bergthaler, Andreas, Igonet, Sebastien, ter Meulen, Jan, Rigo, Dorothée, Meda, Paolo, Rabah, Nadia, Coutard, Bruno, Bowden, Thomas A., Lambert, Paul-Henri, Siegrist, Claire-Anne, Pinschewer, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654586/
https://www.ncbi.nlm.nih.gov/pubmed/26587982
http://dx.doi.org/10.1371/journal.ppat.1005276

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