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Cell-mediated fiber recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments
To investigate how cells sense stiffness in settings structurally similar to native extracellular matrices (ECM), we designed a synthetic fibrous material with tunable mechanics and user-defined architecture. In contrast to flat hydrogel surfaces, these fibrous materials recapitulated cell-matrix in...
Autores principales: | Baker, Brendon M., Trappmann, Britta, Wang, William Y., Sakar, Mahmut S., Kim, Iris L., Shenoy, Vivek B., Burdick, Jason A., Chen, Christopher S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654682/ https://www.ncbi.nlm.nih.gov/pubmed/26461445 http://dx.doi.org/10.1038/nmat4444 |
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