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Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
The functional dynamics and cellular sources of oxidative stress are central to understanding MS pathogenesis but remain elusive, due to the lack of appropriate detection methods. Here we employ NAD(P)H fluorescence lifetime imaging to detect functional NADPH oxidases (NOX enzymes) in vivo to identi...
Autores principales: | Mossakowski, Agata A., Pohlan, Julian, Bremer, Daniel, Lindquist, Randall, Millward, Jason M., Bock, Markus, Pollok, Karolin, Mothes, Ronja, Viohl, Leonard, Radbruch, Moritz, Gerhard, Jenny, Bellmann-Strobl, Judith, Behrens, Janina, Infante-Duarte, Carmen, Mähler, Anja, Boschmann, Michael, Rinnenthal, Jan Leo, Füchtemeier, Martina, Herz, Josephine, Pache, Florence C., Bardua, Markus, Priller, Josef, Hauser, Anja E., Paul, Friedemann, Niesner, Raluca, Radbruch, Helena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654749/ https://www.ncbi.nlm.nih.gov/pubmed/26521072 http://dx.doi.org/10.1007/s00401-015-1497-x |
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