Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS

In neuromyelitis optica (NMO), astrocytes become targets for pathogenic aquaporin 4 (AQP4)-specific antibodies which gain access to the central nervous system (CNS) in the course of inflammatory processes. Since these antibodies belong to a T cell-dependent subgroup of immunoglobulins, and since NMO...

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Detalles Bibliográficos
Autores principales: Zeka, Bleranda, Hastermann, Maria, Hochmeister, Sonja, Kögl, Nikolaus, Kaufmann, Nathalie, Schanda, Kathrin, Mader, Simone, Misu, Tatsuro, Rommer, Paulus, Fujihara, Kazuo, Illes, Zsolt, Leutmezer, Fritz, Sato, Douglas Kazutoshi, Nakashima, Ichiro, Reindl, Markus, Lassmann, Hans, Bradl, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654751/
https://www.ncbi.nlm.nih.gov/pubmed/26530185
http://dx.doi.org/10.1007/s00401-015-1501-5

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